Especially heavy layoffs at Google Flights, including senior managers and engineers who joined Google with the ITA Software acquisition in 2011, could signal strategy shifts in the company’s multifaceted airline business, Skift has learned. Any modifications to Google’s airline strategy could potentially have implications for airline partners, global distribution systems Sabre and Amadeus, metasearch rivals such as Kayak and Skyscanner, as well as travelers. Google delivered its largest layoffs ever — about 12,000 employees, or around 6 percent of its full-time workforce — 10 days ago, and it is believed that firings at Google Flights, which had 100 or more employees on its engineering team alone, reached 10-12 percent. The…